Crainic, Alina-Mariana, Callisti, Mauro, Palmer, Martin and Cook, Richard (2018) Investigation of nano-sized debris released from CoCrMo secondary interfaces in total hip replacements: digestion of the flakes. Journal of Biomedical Materials Research Part B: Applied Biomaterials, . (doi:10.1002/jbm.b.34134).
Record type: Article
The in vivo release of wear debris and corrosion products from the metallic interfaces of total hip replacements is associated with a wide spectrum of adverse body reactions and systemic manifestations. The origin of debris and the electrochemical conditions at the sites of material loss both play a role in determining the physicochemical characteristics of the particles, and thus influence their in vivo reactivity. Debris retrieved from revised CoCrMo tapers and cement-stem interfaces consists of heterogeneous flakes that comprise mechanically mixed metal particles, corrosion products and organic material. Detailed investigation of the size and composition of the metal debris contained within these composites requires the digestion of the flakes to release the small metal particles. Here, we compare alkaline and enzymatic digestion methods that both aim to fragment the flakes and reveal their smallest building blocks. The characterisation of debris cleaned with both methods revealed crystalline Cr oxide nanoparticles and clusters. Comparison between the treatments showed that the alkaline method is more efficient in fragmenting the flakes and provided cleaner and generally smaller nanoparticles than exhibited in debris released with the enzymatic treatment. The provision of cleaner nanoparticles from the alkaline method also allows the physicochemical properties of the particles to be more clearly identified.
Text Crainic_et_al-2017-Journal_of_Biomedical_Materials_Research_Part_B__Applied_Biomaterials – Version of Record
Restricted to Repository staff only until 15 April 2019.
Accepted/In Press date: 23 March 2018
e-pub ahead of print date: 16 April 2018
Local EPrints ID: 421550
PURE UUID: 691bf042-a70e-43ac-8fef-b41eaa4d879e
Date deposited: 14 Jun 2018 16:31
Last modified: 14 Jun 2018 16:31
Author: Alina-Mariana Crainic
Author: Mauro Callisti
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